Ultra-short-course and intermittent TB47-containing oral regimens produce stable cure against Buruli ulcer in a murine model and prevent the emergence of resistance for

Author: Yamin GAO ¹ ; H M Adnan HAMEED ¹ ; Yang LIU ¹ ; Lingmin GUO ¹ ; Cuiting FANG ¹ ; Xirong TIAN ¹ ; Zhiyong LIU ¹ ; Shuai WANG ¹ ; Zhili LU ¹ ; Md Mahmudul ISLAM ¹ ; Tianyu ZHANG ¹
Author Information

1. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Publication Type:Journal Article
Keywords: Buruli ulcer; Chemotherapy; Clofazimine; Drug resistance; Electron transport chain; Mycobacterium ulcerans; QcrB; TB47
From: Acta Pharmaceutica Sinica B 2021;11(3):738-749
CountryChina
Language:English
Abstract: Buruli ulcer (BU), caused by