Can nanoparticles and nano‒protein interactions bring a bright future for insulin delivery?
10.1016/j.apsb.2020.08.016
- Author:
Ting ZHANG
1
;
James Zhenggui TANG
2
;
Xiaofan FEI
1
;
Yanping LI
3
;
Yi SONG
1
;
Zhiyong QIAN
4
;
Qiang PENG
5
Author Information
1. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
2. Research Institute in Healthcare Science, Faculty of Science and Engineering, School of Pharmacy, University of Wolverhampton, Wolverhampton, WV1 1LY, UK.
3. Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital of Sichuan University, Chengdu 610041, China.
4. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China.
5. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
- Publication Type:Review
- Keywords:
Absorption;
Controlled release;
Diabetic;
Insulin;
Nanomaterials;
Protein adsorption
- From:
Acta Pharmaceutica Sinica B
2021;11(3):651-667
- CountryChina
- Language:English
-
Abstract:
Insulin therapy plays an essential role in the treatment of diabetes mellitus. However, frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance. In order to improve insulin delivery, many efforts have been made, such as developing the nanoparticles (NPs)-based release systems and oral insulin. Although some improvements have been achieved, the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far. Recently, nano‒protein interactions and protein corona formation have drawn much attention due to their negative influence on the
