Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment.
10.1016/j.apsb.2020.10.022
- Author:
Jinghui ZHANG
1
;
Jiajun FAN
2
;
Xian ZENG
2
;
Mingming NIE
1
;
Jingyun LUAN
2
;
Yichen WANG
2
;
Dianwen JU
2
;
Kai YIN
1
Author Information
1. Department of Gastrointestinal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
2. Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.
- Publication Type:Review
- Keywords:
5-Fu, 5-fluorouracil;
ALK5, TGF-β receptor I kinase;
ATO, arsenic trioxide;
BCC, basal cell carcinoma;
BCL-2, B cell lymphoma 2;
BMI-1, B cell-specific moloney murine leukemia virus insertion region-1;
CAFs, cancer-associated fibroblasts;
CSCs, cancer stem cells;
Cancer stem cells;
Carcinogenesis;
DHH, Desert Hedgehog;
Drug resistance;
EGF, epidermal growth factor;
FOLFOX, oxaliplatin;
G protein coupled receptor kinase 2, HH;
Gastrointestinal cancer;
Hedgehog;
Hedgehog, HIF-1α;
IHH, Indian Hedgehog;
IL-10/6, interleukin 10/6;
ITCH, itchy E3 ubiquitin ligase;
MDSCs, myeloid-derived suppressor cells;
NK, natural killer;
NOX4, NADPH Oxidase 4;
PD-1, programmed cell death-1;
PD-L1, programmed cell death ligand-1;
PKA, protein kinase A;
PTCH, Patched;
ROS, reactive oxygen species;
SHH, Sonic Hedgehog;
SMAD3, mothers against decapentaplegic homolog 3;
SMO, Smoothened;
SNF5, sucrose non-fermenting 5;
STAT3, signal transducer and activator of transcription 3;
SUFU, Suppressor of Fused;
TAMs, tumor-related macrophages;
TGF-β, transforming growth factor β;
TME, tumor microenvironment;
Tumor microenvironment;
VEGF, vascular endothelial growth factor;
WNT, Wingless/Integrated;
and leucovorin, GLI;
ch5E1, chimeric monoclonal antibody 5E1;
glioma-associated oncogene homologue, GRK2;
hypoxia-inducible factor 1α, IFN-γ: interferon-γ;
βArr2, β-arrestin2
- From:
Acta Pharmaceutica Sinica B
2021;11(3):609-620
- CountryChina
- Language:English
-
Abstract:
The Hedgehog (HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment (TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance. The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6 (IL-6) and interferon-
