Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products.

Author: Qian WEI ¹ ; Jian BAI ¹ ; Daojiang YAN ¹ ; Xiuqi BAO ¹ ; Wenting LI ² ; Bingyu LIU ¹ ; Dan ZHANG ¹ ; Xiangbing QI ² ; Dequan YU ¹ ; Youcai HU ¹
Author Information

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
2. National Institute of Biological Sciences, Beijing 102206, China.
Publication Type:Journal Article
Keywords: Azaphilones; Endophytic fungi; Genome mining; Metabolic shunting; Penicillium dangeardii; Silent gene cluster; Trimers
From: Acta Pharmaceutica Sinica B 2021;11(2):572-587
CountryChina
Language:English
Abstract: Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus