Hypoxia-degradable and long-circulating zwitterionic phosphorylcholine-based nanogel for enhanced tumor drug delivery.
10.1016/j.apsb.2020.08.012
- Author:
Shaojun PENG
1
;
Boshu OUYANG
2
;
Yongjie XIN
1
;
Wei ZHAO
1
;
Shun SHEN
3
;
Meixiao ZHAN
1
;
Ligong LU
1
Author Information
1. Zhuhai Precision Medical Center, Zhuhai Interventional Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, China.
2. Central Laboratory, First Affiliated Hospital, Institute (College) of Integrative Medicine, Dalian Medical University, Dalian 116021, China.
3. Zhejiang Cancer Hospital, Institute of Cancer Research, Hangzhou 310012, China.
- Publication Type:Journal Article
- Keywords:
Drug delivery;
Drug release;
Hypoxia-degradable;
Long blood circulation;
Zwitterionic nanogel
- From:
Acta Pharmaceutica Sinica B
2021;11(2):560-571
- CountryChina
- Language:English
-
Abstract:
Tumor microenvironment has been widely utilized for advanced drug delivery in recent years, among which hypoxia-responsive drug delivery systems have become the research hotspot. Although hypoxia-responsive micelles or polymersomes have been successfully developed, a type of hypoxia-degradable nanogel has rarely been reported and the advantages of hypoxia-degradable nanogel over other kinds of degradable nanogels in tumor drug delivery remain unclear. Herein, we reported the synthesis of a novel hypoxia-responsive crosslinker and the fabrication of a hypoxia-degradable zwitterionic poly(phosphorylcholine)-based (
