pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy.

Author: Zhiming ZHANG ¹ ; Chenlu HUANG ¹ ; Li ZHANG ¹ ; Qing GUO ¹ ; Yu QIN ¹ ; Fan FAN ¹ ; Boxuan LI ¹ ; Bao XIAO ¹ ; Dunwan ZHU ¹ ; Linhua ZHANG ¹
Author Information

1. Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
Publication Type:Journal Article
Keywords: Bubble-generating; Combination therapy; Mesoporous silica; Targeting modification; pH-sensitive
From: Acta Pharmaceutica Sinica B 2021;11(2):520-533
CountryChina
Language:English
Abstract: Chemotherapy has been a major option in clinic treatment of malignant tumors. However, single chemotherapy faces some drawbacks, such as multidrug resistance, severe side effects, which hinder its clinic application in tumor treatment. Multifunctional nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination therapy. In the current study, a novel pH-sensitive and bubble-generating mesoporous silica-based drug delivery system (denoted as M(a)D@PI-PEG-RGD) was constructed. Ammonium bicarbonate (NH