Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis.
10.1016/j.apsb.2020.08.008
- Author:
Kaiyue YU
1
;
Xiuming YU
1
;
Sisi CAO
1
;
Yixuan WANG
1
;
Yuanhao ZHAI
1
;
Fengdie YANG
1
;
Xiaoyuan YANG
1
;
Yi LU
1
;
Chuanbin WU
1
;
Yuehong XU
1
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
- Publication Type:Journal Article
- Keywords:
Blank-MN, blank layered MNs;
C6, coumarin 6;
CLSM, confocal laser scanning microscope;
DIC, diclofenac sodium;
DIC-MN, layered MNs loading DIC in the tip-layer of needles;
Diclofenac sodium;
HA, hyaluronic acid;
IL-17A, interleukin 17A;
IMQ, imiquimod;
IVISR, in vivo imaging system;
Layered microneedles;
MIX-MN, unlayered MNs loading the mixture of DIC and TAC in needles;
MN, microneedle;
NIC, nicotinamide;
NSAIDs, nonsteroidal anti-inflammatory drugs;
Need-based drug delivery;
OCT, optical coherence tomography;
PASI, psoriasis area and severity index;
PDMS, polydimethylsiloxane;
PVP, polyvinyl pyrrolidone;
PsA, psoriatic arthritis;
Psoriasis;
Psoriatic arthritis;
RhB, rhodamine B;
SC, stratum corneum;
SEM, scanning electron microscope;
TAC, tacrolimus;
TAC-MN, layered MNs loading TAC in the inter-layer of needles;
TD-MN, layered MNs co-loading TAC in the inter-layer of needles and DIC in the tip-layer;
TEWL, transepidermal water loss;
TNF-α, tumor necrosis factor α;
Tacrolimus
- From:
Acta Pharmaceutica Sinica B
2021;11(2):505-519
- CountryChina
- Language:English
-
Abstract:
Psoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains challenging. We developed a need-based layered dissolving microneedle (MN) system loading immunosuppressant tacrolimus (TAC) and anti-inflammatory diclofenac (DIC) in different layers of MNs,
