Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.

Dominik Bakalarz; Marcin Surmiak; Xiaoxiao Yang; Dagmara Wójcik; Edyta Korbut; Zbigniew Śliwowski; Grzegorz Ginter; Grzegorz Buszewicz; Tomasz Brzozowski; Jakub Cieszkowski; Urszula Głowacka; Katarzyna Magierowska; Zhixiang Pan; Binghe Wang; Marcin Magierowski

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Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage.

Author: Dominik BAKALARZ ¹ ; Marcin SURMIAK ¹ ; Xiaoxiao YANG ² ; Dagmara WÓJCIK ¹ ; Edyta KORBUT ¹ ; Zbigniew ŚLIWOWSKI ¹ ; Grzegorz GINTER ¹ ; Grzegorz BUSZEWICZ ³ ; Tomasz BRZOZOWSKI ¹ ; Jakub CIESZKOWSKI ¹ ; Urszula GŁOWACKA ¹ ; Katarzyna MAGIEROWSKA ¹ ; Zhixiang PAN ² ; Binghe WANG ² ; Marcin MAGIEROWSKI ¹
Author Information

1. Department of Physiology, Jagiellonian University Medical College, Cracow 31-531, Poland.
2. Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
3. Department of Forensic Medicine, Medical University of Lublin, Lublin 20-093, Poland.
Publication Type:Journal Article
Keywords: Anti-inflammation; Carbon monoxide; Ethanol; Gastric mucosal damage; Gastroprotection; NSAID; Prodrug
From: Acta Pharmaceutica Sinica B 2021;11(2):456-475
CountryChina
Language:English
Abstract: Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity. We are interested in further development of metal-free CO-based therapeutics for oral administration. Thus, we examine the protective effect of representative CO prodrug, BW-CO-111, in rat models of gastric damage induced by necrotic ethanol or aspirin, a representative non-steroidal anti-inflammatory drug. Treatment effectiveness was assessed by measuring the microscopic/macroscopic gastric damage area and gastric blood flow by laser flowmetry. Gastric mucosal mRNA and/or protein expressions of HMOX1, HMOX2, nuclear factor erythroid 2-related factor 2, COX1, COX2,