SUV39H1 deficiency suppresses clear cell renal cell carcinoma growth by inducing ferroptosis.

Author: Jianfeng WANG ¹ ; Xiaomao YIN ¹ ; Wei HE ² ; Wei XUE ¹ ; Jin ZHANG ¹ ; Yiran HUANG ¹
Author Information

1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
2. Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Publication Type:Journal Article
Keywords: Clear cell renal cell carcinoma; DPP4; Epigenetics; Ferroptosis; Prognostic model; Progression; SUV39H1; Therapeutic target
From: Acta Pharmaceutica Sinica B 2021;11(2):406-419
CountryChina
Language:English
Abstract: Clear cell renal cell carcinoma (ccRCC) is a common kidney malignancy characterized by a poor prognosis. Suppressor of variegation 3-9 homolog 1 (