Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics.
10.1016/j.apsb.2020.09.001
- Author:
David DOLIVO
1
;
Pamela WEATHERS
2
;
Tanja DOMINKO
2
Author Information
1. Department of Surgery, Northwestern University-Feinberg School of Medicine, Chicago, IL 60611, USA.
2. Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
- Publication Type:Review
- Keywords:
ALP, alkaline phosphatase;
ALT, alanine aminotransferase;
AMPK, AMP-activated protein kinase;
ASP, aspartate aminotransferase;
Artemisia;
Artemisinin;
Artesunate;
BAD, BCL-2-associated agonist of cell death;
BDL, bile duct ligation;
BSA, bovine serum albumin;
BUN, blood urea nitrogen;
CCl4, carbon tetrachloride;
CTGF, connective tissue growth factor;
Col I, type I collagen;
DHA, dihydroartemisinin;
DLA, dried leaf Artemisia;
ECM, extracellular matrix;
EMT, epithelial-to-mesenchymal transition;
FLS, fibroblast-like synoviocyte;
Fibroblast;
Fibrosis;
HA, hyaluronic acid;
HSC, hepatic stellate cell;
HUVEC, human umbilical vein endothelial cell;
LAP, latency-associated peptide;
LDH, lactate dehydrogenase;
MAPK, mitogen-activated protein kinase;
MI, myocardial infarction;
MMP, matrix metalloproteinase;
Myofibroblast;
NAG, N-acetyl-β-d-glucosaminidase;
NICD, Notch intracellular domain;
PCNA, proliferating cell nuclear antigen;
PHN, passive heymann nephritis;
ROS, reactive oxygen species;
STZ, streptozotocin;
Scar;
TGF, β-transforming growth factor-β;
TGF-β;
TIMP, tissue inhibitor of metalloproteinase;
UUO, unilateral ureteral obstruction;
i.p., intraperitoneal;
mTOR, mechanistic target of rapamycin;
sCr, serum creatinine;
α-SMA, smooth muscle α-actin
- From:
Acta Pharmaceutica Sinica B
2021;11(2):322-339
- CountryChina
- Language:English
-
Abstract:
Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis. Artemisinin compounds are best known as antimalarial therapeutics, but they also demonstrate antiparasitic, antibacterial, anticancer, and anti-fibrotic effects. Here we summarize literature describing anti-fibrotic effects of artemisinin compounds in
