Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment.
10.1016/j.apsb.2020.08.009
- Author:
Xiaojie CHEN
1
;
Jiafeng ZOU
1
;
Ke ZHANG
1
;
Jingjing ZHU
1
;
Yue ZHANG
1
;
Zhihong ZHU
1
;
Hongyue ZHENG
2
;
Fanzhu LI
1
;
Ji-Gang PIAO
1
Author Information
1. College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
2. Libraries of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Hangzhou 310053, China.
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Chemo–photothermal therapy;
Doxorubicin;
Gelatin;
Indocyanine green;
MMP-2;
Nanoparticle;
Size-variable
- From:
Acta Pharmaceutica Sinica B
2021;11(1):271-282
- CountryChina
- Language:English
-
Abstract:
The chemotherapy combined with photothermal therapy has been a favorable approach for the treatment of breast cancer. In present study, nanoparticles with the characteristics of photothermal/matrix metalloproteinase-2 (MMP-2) dual-responsive, tumor targeting, and size-variability were designed for enhancing the antitumor efficacy and achieving "on-demand" drug release markedly. Based on the thermal sensitivity of gelatin, we designed a size-variable gelatin nanoparticle (GNP) to encapsulate indocyanine green (ICG) and doxorubicin (DOX). Under an 808 nm laser irradiation, GNP-DOX/ICG responded photothermally and swelled in size from 71.58 ± 4.28 to 160.80 ± 9.51 nm, which was beneficial for particle retention in the tumor sites and release of the loaded therapeutics. Additionally, GNP-DOX/ICG showed a size reduction of the particles to 33.24 ± 4.11 nm and further improved drug release with the degradation of overexpressed MMP-2 in tumor. In the subsequently performed
