A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy.

Bingchen Zhang; Jiali Jiang; Pengyu WU; Junjie Zou; Jingqing LE; Juanfang Lin; Chao LI; Bangyue Luo; Yongjie Zhang; Rui Huang; Jingwei Shao

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A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy.

Author: Bingchen ZHANG ¹ ; Jiali JIANG ¹ ; Pengyu WU ¹ ; Junjie ZOU ¹ ; Jingqing LE ¹ ; Juanfang LIN ¹ ; Chao LI ¹ ; Bangyue LUO ¹ ; Yongjie ZHANG ¹ ; Rui HUANG ² ; Jingwei SHAO ¹
Author Information

1. Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China.
2. Institute of Oceanography, Minjiang University, Fuzhou 350108, China.
Publication Type:Journal Article
Keywords: Aptamer; Co-assembly; EGCG; HCC; Immunotherapy; Nanodrug; Natural product; Synergistic treatment; Ursolic acid
From: Acta Pharmaceutica Sinica B 2021;11(1):246-257
CountryChina
Language:English
Abstract: Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent delivery. However, the potential toxicity and unclear internal metabolism of most nano-carriers was still a major obstacle for the clinical application. Herein, a novel "core‒shell" co-assembly carrier-free nanosystem was constructed based on natural sources of ursolic acid (UA) and polyphenol (EGCG) with the EpCAM-aptamer modification for hepatocellular carcinoma (HCC) synergistic treatment. As the nature products derived from food-plant, UA and EGCG had good anticancer activities and low toxicity. With the simple and "green" method, the nanodrugs had the advantages of good stability, pH-responsive and strong penetration of tumor tissues, which was expected to increase tumor cellular uptake, long circulation and effectively avoid the potential defects of traditional carriers. The nanocomplex exhibited the low cytotoxicity in the normal cells