A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility.
10.1016/j.apsb.2020.07.018
- Author:
Yixian ZHOU
1
;
Boyi NIU
1
;
Biyuan WU
1
;
Sulan LUO
1
;
Jintao FU
1
;
Yiting ZHAO
1
;
Guilan QUAN
2
;
Xin PAN
1
;
Chuanbin WU
1
Author Information
1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
2. College of Pharmacy, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- Keywords:
ANOVA, analysis of variance;
BALF, bronchoalveolar lavage fluid;
BET, Brunauer–Emmett–Teller;
CCK-8, cell counting kit-8;
CD-MOF, cyclodextrin-based metal-organic framework;
CD-MOF-K, ketoprofen-loaded cyclodextrin-based metal-organic framework;
CD-MOF-R, rhodamine B-loaded cyclodextrin-based metal-organic framework;
CF, commercial formulation;
CTAB, cetyl trimethyl ammonium bromide;
Cdyn, dynamic lung compliance;
DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine;
FBS, fetal bovine serum;
FDA, U.S. Food and Drug Administration;
FPF, fine particle fraction;
GSD, geometric standard deviation;
HE, Hematoxylin-Eosin;
HPLC, high performance liquid chromatography;
Inhalable dry powder;
LDH, lactate dehydrogenase;
LPS, lipopolysaccharide;
MFI, mean fluorescence intensity;
MMAD, mean mass aerodynamic diameter;
MOF, metal-organic framework;
Metal-organic framework;
NGI, next generation pharmaceutical impactor;
Nanoporous particle;
PBS, phosphate buffered solution;
PVP, poly(vinyl pyrrolidone);
PXRD, powder X-ray diffraction;
Pulmonary drug delivery;
Rl, lung resistance;
SD rat, Sprague–Dawley rat;
SEM, scanning electron microscopy;
SLF, simulated lung fluid;
γ-CD, γ-cyclodextrin
- From:
Acta Pharmaceutica Sinica B
2020;10(12):2404-2416
- CountryChina
- Language:English
-
Abstract:
Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens. Compared with commercial inhalation carrier, CD-MOF showed excellent aerosolization performance because of the homogenous nanoporous structure. The great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments, including cytotoxicity assay, hemolysis ratio test, lung function evaluation,
