CORM-2-entrapped ultradeformable liposomes ameliorate acute skin inflammation in an ear edema model
- Author:
Gwan-Yeong LEE
1
;
Alam ZEB
1
;
Eun-Hye KIM
1
;
Beomseon SUH
1
;
Young-Jun SHIN
1
;
Donghyun KIM
1
;
Kyoung-Won KIM
1
;
Yeong-Hwan CHOE
1
;
Ho-Ik CHOI
1
;
Cheol-Ho LEE
1
;
Omer Salman QURESHI
2
;
In-Bo HAN
3
;
Sun-Young CHANG
4
;
Ok-Nam BAE
1
;
Jin-Ki KIM
1
Author Information
- Publication Type:Journal Article
- Keywords: Anti-inflammatory effect; CORM-2; Carbon monoxide; Ear edema; Skin inflammation; Ultradeformable liposomes
- From: Acta Pharmaceutica Sinica B 2020;10(12):2362-2373
- CountryChina
- Language:English
- Abstract: The short release half-life of carbon monoxide (CO) is a major obstacle to the effective therapeutic use of carbon monoxide-releasing molecule-2 (CORM-2). The potential of CORM-2-entrapped ultradeformable liposomes (CORM-2-UDLs) to enhance the release half-life of CO and alleviate skin inflammation was investigated in the present study. CORM-2-UDLs were prepared by using soy phosphatidylcholine to form lipid bilayers and Tween 80 as an edge activator. The deformability of CORM-2-UDLs was measured and compared with that of conventional liposomes by passing formulations through a filter device at a constant pressure. The release profile of CO from CORM-2-UDLs was evaluated by myoglobin assay.
