GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy.
10.1016/j.apsb.2020.10.009
- Author:
Congcong LIN
1
;
Fan TONG
2
;
Rui LIU
2
;
Rou XIE
2
;
Ting LEI
2
;
Yuxiu CHEN
2
;
Zhihang YANG
2
;
Huile GAO
2
;
Xiangrong YU
1
Author Information
1. Department of Radiology, Zhuhai People's Hospital, Jinan University, Zhuhai 519000, China.
2. Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Sichuan 610041, China.
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Ce6;
Chemo-photodynamic therapy;
Co-administration;
GSH-responsive;
SN38 dimer;
Shape-transformable;
iRGD
- From:
Acta Pharmaceutica Sinica B
2020;10(12):2348-2361
- CountryChina
- Language:English
-
Abstract:
Accurate tumor targeting, deep penetration and superb retention are still the main pursuit of developing excellent nanomedicine. To achieve these requirements, a stepwise stimuli-responsive strategy was developed through co-administration tumor penetration peptide iRGD with shape-transformable and GSH-responsive SN38-dimer (d-SN38)-loaded nanoparticles (d-SN38@NPs/iRGD). Upon intravenous injection, d-SN38@NPs with high drug loading efficiency (33.92 ± 1.33%) could effectively accumulate and penetrate into the deep region of tumor sites with the assistance of iRGD. The gathered nanoparticles simultaneously transformed into nanofibers upon 650 nm laser irradiation at tumor sites so as to promote their retention in the tumor and burst release of reactive oxygen species for photodynamic therapy. The loaded d-SN38 with disulfide bond responded to the high level of GSH in tumor cytoplasm, which consequently resulted in SN38 release and excellent chemo-photodynamic effect on tumor.
