Targeting castration-resistant prostate cancer with a novel ROR

Jianwei Zheng; Junfeng Wang; Qian Wang; Hongye Zou; Hong Wang; Zhenhua Zhang; Jianghe Chen; Qianqian Wang; Panxia Wang; Yueshan Zhao; Jing LU; Xiaolei Zhang; Songtao Xiang; Haibin Wang; Jinping Lei; Hong-wu Chen; Peiqing Liu; Yonghong Liu; Fanghai Han; Junjian Wang

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Targeting castration-resistant prostate cancer with a novel ROR

Author: Jianwei ZHENG ¹ ; Junfeng WANG ² ; Qian WANG ¹ ; Hongye ZOU ³ ; Hong WANG ¹ ; Zhenhua ZHANG ¹ ; Jianghe CHEN ¹ ; Qianqian WANG ¹ ; Panxia WANG ¹ ; Yueshan ZHAO ¹ ; Jing LU ¹ ; Xiaolei ZHANG ¹ ; Songtao XIANG ⁴ ; Haibin WANG ⁵ ; Jinping LEI ¹ ; Hong-Wu CHEN ³ ; Peiqing LIU ¹ ; Yonghong LIU ² ; Fanghai HAN ⁶ ; Junjian WANG ¹
Author Information

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
2. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
3. Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
4. Department of Urology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
5. Department of Joint Orthopaedic, the First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
6. Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Publication Type:Journal Article
Keywords: Antagonist; Castration-resistant prostate cancer; Elaiophylin; Nuclear receptor; RORγ
From: Acta Pharmaceutica Sinica B 2020;10(12):2313-2322
CountryChina
Language:English
Abstract: Prostate cancer (PCa) patients who progress to metastatic castration-resistant PCa (mCRPC) mostly have poor outcomes due to the lack of effective therapies. Our recent study established the orphan nuclear receptor ROR