Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement

Author: Yaoyao LUO ¹ ; Jingjing LI ² ; Yichen HU ³ ; Fei GAO ¹ ; George PAK-HENG LEUNG ² ; Funeng GENG ¹ ; Chaomei FU ¹ ; Jinming ZHANG ¹
Author Information

1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. Department of Pharmacology and Pharmacy, University of Hong Kong, HongKong 999077, China.
3. College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610100, China.
Publication Type:Journal Article
Keywords: Anti-angiogenesis; Breast cancer; Micelle; Pro-apoptosis; Survival rate; Thermo-responsive hydrogel; Triptolide; Tumor local treatment
From: Acta Pharmaceutica Sinica B 2020;10(11):2227-2245
CountryChina
Language:English
Abstract: The clinical application of triptolide (TPL) in tumor therapy has been greatly limited by its toxicity and inefficient delivery. Herein, a localized and sustained-release thermo-sensitive hydrogel was developed for the intra-tumor administration of TPL. Based on the amphiphilic structure of poly (