Dual-targeting nanovesicles enhance specificity to dynamic tumor cells
10.1016/j.apsb.2020.07.012
- Author:
Yang SONG
1
;
Xiangfu GUO
1
;
Jijun FU
2
;
Bing HE
1
;
Xueqing WANG
1
;
Wenbing DAI
1
;
Hua ZHANG
1
;
Qiang ZHANG
1
Author Information
1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
2. Guangzhou Medical University, School of Pharmaceutical Sciences, Guangzhou 511436, China.
- Publication Type:Journal Article
- Keywords:
C6, coumarin-6;
CTCs, circulating tumor cells;
Circulating tumor cells;
DOX, doxorubicin;
DT4, d-thyroxine;
Dual-targeting;
EPR, enhanced permeability and retention;
FSS, fluidic shear stress;
Flowing condition;
Fluidic shear stress;
LIPO, lipid vesicles;
Leukemia;
Lipid vesicle;
PDI, polydispersity index;
PET, positron emission computed tomography;
RGD, Arginine-glycine-aspartic acid;
RGDm7, cRGD-ACP-K;
ROI, regions of interests;
SPR, surface plasmon resonance;
T3, 3,3′,5-triiodothyronine;
T4, thyroxine
- From:
Acta Pharmaceutica Sinica B
2020;10(11):2183-2197
- CountryChina
- Language:English
-
Abstract:
The dynamic or flowing tumor cells just as leukemia cells and circulating tumor cells face a microenvironment difference from the solid tumors, and the related targeting nanomedicines are rarely reported. The existence of fluidic shear stress in blood circulation seems not favorable for the binding of ligand modified nanodrugs with their target receptor. Namely, the binding feature is very essential in this case. Herein, we utilized HSPC, PEG-DSPE, cholesterol and two
