Natural products remodel cancer-associated fibroblasts in desmoplastic tumors.
10.1016/j.apsb.2020.04.005
- Author:
Rujing CHEN
1
;
Leaf HUANG
2
;
Kaili HU
1
Author Information
1. Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- Publication Type:Review
- Keywords:
Cancer treatment;
Cancer-associated fibroblasts;
Desmoplastic tumors;
Extracellular matrix;
Natural products;
Traditional Chinese medicine;
Tumor microenvironment
- From:
Acta Pharmaceutica Sinica B
2020;10(11):2140-2155
- CountryChina
- Language:English
-
Abstract:
Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the malignancy. Recently, through modulating cancer-associated fibroblasts (CAFs) which are the most abundant cell type among all stromal cells, natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells, showing promising ability to improve treatment effects on desmoplastic tumors. In this review, we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products, highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment.
