The progress and perspective of nanoparticle-enabled tumor metastasis treatment.
10.1016/j.apsb.2020.07.013
- Author:
Wei ZHANG
1
;
Fei WANG
1
;
Chuan HU
2
;
Yang ZHOU
2
;
Huile GAO
2
;
Jiang HU
1
Author Information
1. Department of Orthopedics, Sichuan Provincial People's Hospital & Sichuan Academy of Medical Sciences & Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China.
2. Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu 610041, China.
- Publication Type:Review
- Keywords:
Ferroptosis;
Immunotherapy;
Nanoparticles;
Nanovaccines;
Photodynamic therapy;
Stimulating immune response;
Tumor metastasis;
Tumor targeting drug delivery
- From:
Acta Pharmaceutica Sinica B
2020;10(11):2037-2053
- CountryChina
- Language:English
-
Abstract:
As one of the most serious threats to human being, cancer is hard to be treated when metastasis happens. What's worse, there are few identified targets of metastasis for drug development. Therefore, it is important to develop strategies to prevent metastasis or treat existed metastasis. This review focuses on the procedure of metastasis, and first summarizes the targeting delivery strategies, including primary tumor targeting drug delivery, tumor metastasis targeting drug delivery and hijacking circulation cells. Then, as a promising treatment, the application of immunotherapy in tumor metastasis treatment is introduced, and strategies that stimulating immune response are reviewed, including chemotherapy, photothermal therapy, photodynamic therapy, ferroptosis, sonodynamic therapy, and nanovaccines. Finally, the challenges and perspective about nanoparticle-enabled tumor metastasis treatment are discussed.
