Systematic chemical characterization of Xiexin decoctions using high performance liquid chromatography coupled with electrospray ionization mass spectrometry.
10.1016/S1875-5364(21)60045-6
- Author:
Li-Juan SHEN
1
;
Ke-Di LUO
1
;
Xue-Xun WEN
1
;
Shu-Fang WANG
1
;
Xiao-Hui FAN
2
,
3
Author Information
1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
2. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
3. State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address: fanxh@zju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Analogous formulae;
HPLC-MS;
Systematic chemical characterization;
Traditional Chinese Medicine;
Xiexin decoctions
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(6):464-472
- CountryChina
- Language:English
-
Abstract:
Xiexin decoctions (XXDs) display beneficial anti-inflammatory and anti-diabetic effects, which raises interests on this group of formulae for broad clinical applications. However, there was no report about systematic analysis of XXDs to elucidate the constitution of chemical components, which hampers further investigations on the therapeutic values of XXDs. In this work, crude herbs were extracted and prepared to obtain the XXDs for systemic analysis on their chemical compositions, according to the information described in the ancient Zhang Zhongjing's herbal formulae. LC-MS analysis of five XXDs was carried out to facilitate recognition of the source herbs for compounds in the mixture. A total number of 93 compounds were identified through our methods and their chemical classes encompassed five major groups, including protoberberine alkaloids, flavonoids, stilbenes, anthraquinones and saponins. Our current work provided important information about material basis for pharmacological studies on XXDs and would help shed light on relationships between chemical compositions and therapeutic effects.
