A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan.
10.1016/S1875-5364(21)60034-1
- Author:
Dou-Dou XU
1
;
Xiao-Ying HOU
1
;
Ou WANG
1
;
Di WANG
1
;
Dan-Ting LI
1
;
Si-Yuan QIN
1
;
Bo LV
1
;
Xiao-Min DAI
1
;
Zun-Jian ZHANG
1
;
Jian-Bo WAN
2
;
Feng-Guo XU
3
Author Information
1. Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address: jbwan@um.edu.mo.
3. Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China. Electronic address: fengguoxu@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Active components;
Bioactivity contribution;
Huang-Qin Decoction;
Irinotecan;
Toxicity attenuating and efficacy enhancing
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(5):364-375
- CountryChina
- Language:English
-
Abstract:
Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11. First, the potential bioactive constituents were obtained through system pharmacology strategy. Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration, TNF-α release of THP-1-derived macrophage and MTT assay in HCT116 cell. The contribution of each constituent in HQD was evaluated using the bioactive index E
