Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy.
10.1016/S1875-5364(21)60026-2
- Author:
Jian-Zhi WU
1
;
Ya-Jing LI
1
;
Guang-Rui HUANG
2
;
Bing XU
3
;
Fei ZHOU
3
;
Run-Ping LIU
3
;
Feng GAO
3
;
Jun-De GE
3
;
Ya-Jie CAI
3
;
Qi ZHENG
3
;
Xiao-Jiaoyang LI
4
Author Information
1. School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
2. School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: hgr@bucm.edu.cn.
3. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
4. School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: xiaojiaoyang.li@bucm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Angelicae Sinensis Radix;
Herb-pair;
Ligusticum Chuanxiong Rhizoma;
Liver fibrosis;
Network pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(4):241-254
- CountryChina
- Language:English
-
Abstract:
Angelicae Sinensis Radix (Danggui) and Ligusticum Chuanxiong Rhizoma (Chuan Xiong) herb-pair (DC) have been frequently used in Traditional Chinese medicine (TCM) prescriptions for hundreds of years to prevent vascular diseases and alleviate pain. However, the mechanism of DC herb-pair in the prevention of liver fibrosis development was still unclear. In the present study, the effects and mechanisms of DC herb-pair on liver fibrosis were examined using network pharmacology and mouse fibrotic model. Based on the network pharmacological analysis of 13 bioactive ingredients found in DC, a total of 46 targets and 71 pathways related to anti-fibrosis effects were obtained, which was associated with mitogen-activated protein kinase (MAPK) signal pathway, hepatic inflammation and fibrotic response. Furthermore, this hypothesis was verified using carbon tetrachloride (CCl
