Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits.
10.1016/S1875-5364(21)60019-5
- Author:
Yan-Chen HE
1
;
Yu-Min YAO
1
;
Qiu-Wen XUE
1
;
Xin FANG
2
;
Shuang LIANG
3
Author Information
1. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: felix.fx@163.com.
3. Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: ls7312@163.com.
- Publication Type:Journal Article
- Keywords:
Anti-rheumatoid arthritis;
Diterpenoid fraction;
Mechanism;
Rhododendron molle
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(3):181-187
- CountryChina
- Language:English
-
Abstract:
Rhododendron molle G. Don is first recorded in Shengnong's Herbal Classic, and its fruits, which are termed as Liuzhouzi, are often used to treat rheumatoid arthritis in Chinese folk. During our ongoing investigation to develop a safer and potential new arthritis therapy, a process for the preparation of diterpenoid fraction from Rhododendron mollefruits was established. In order to evaluate the main components and the anti-rheumatoid arthritis effect of the diterpenoid fraction, phytochemical and pharmacological experiments were used. As the result, the main components of diterpenoid fraction were identified as rhodojaponin III (1), rhodojaponin VI (2), 2-O-methylrhodojaponin (3), and 5'-β-D-glucopyranosy-loxyjasmonic acid (4). These four components constitute greater than 95% of diterpenoid fraction using area normalization method of HPLC-ELSD. The results of CIA rat experiment showed that high dose of diterpenoid fraction (0.6 mg·kg
