Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410.
10.1016/S1875-5364(20)60040-1
- Author:
Wei LI
1
;
Jing WEI
1
;
Dao-Ying CHEN
1
;
Mei-Jing WANG
2
;
Yang SUN
2
;
Fang-Wen JIAO
1
;
Rui-Hua JIAO
1
;
Ren-Xiang TAN
3
,
4
;
Hui-Ming GE
5
Author Information
1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
2. State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Science, Nanjing University, Nanjing 210023, China.
3. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China
4. State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: rxtan@nju.edu.cn.
5. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address: hmge@nju.edu.cn.
- Publication Type:Journal Article
- Keywords:
Grasshopper-associated fungi;
Inhibitory activity;
SHP2;
Secondary metabolites;
Structure elucidation
- MeSH:
Anhydrides/pharmacology*;
Animals;
Biological Products/pharmacology*;
Enzyme Inhibitors/pharmacology*;
Fungi/chemistry*;
Grasshoppers/microbiology*;
Molecular Structure;
Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors*;
Secondary Metabolism
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(12):957-960
- CountryChina
- Language:English
-
Abstract:
Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A (1) and B (2), along with three known compounds 3-5, were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.
