New furo3,2-hisochroman from the mangrove endophytic fungus Aspergillus sp. 085242.
10.1016/S1875-5364(20)60028-0
- Author:
Hui-Xian GUO
1
;
Cui-Ying HUANG
1
;
Zhang-Yuan YAN
1
;
Tao CHEN
1
;
Kui HONG
2
;
Yu-Hua LONG
3
Author Information
1. School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.
2. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
3. School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China. Electronic address: longyh@scnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Antimicrobial activity;
Aspergillus;
Furo[3, 2-h]isocoumarins;
α-Glucosidase inhibitory activity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(11):855-859
- CountryChina
- Language:English
-
Abstract:
Four new compounds, asperisocoumarin G (1), asperisocoumarin H (2), (±)-asperisocoumarin I [(±)-3], along with the known pergillin (4) and penicisochroman L (5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I (1-3) were new isocoumarins belonging to the class of furo[3, 2-h]isocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for their α-glucosidase inhibitory effects, and compounds 1 and 4 showed moderate α-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of 3 showed antibacterial activity against Salmonella.
