Penicacids E-G, three new mycophenolic acid derivatives from the marine-derived fungus Penicillium parvum HDN17-478.
10.1016/S1875-5364(20)60027-9
- Author:
Xiao-Hui CHEN
1
;
Guo-Liang ZHOU
1
;
Chun-Xiao SUN
1
;
Xiao-Min ZHANG
1
;
Guo-Jian ZHANG
2
,
3
;
Tian-Jiao ZHU
2
,
3
;
Jing LI
1
;
Qian CHE
2
,
4
;
De-Hai LI
2
,
3
Author Information
1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
2. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
3. Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
4. Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, 266237, China. Electronic address: cheqian064@ouc.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cytotoxicity;
Marine-derived fungus;
Mycophenolic acid derivatives;
Penicillium parvum
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(11):850-854
- CountryChina
- Language:English
-
Abstract:
Three new mycophenolic acid derivatives, penicacids E-G (1-3), together with three known analogues, mycophenolic acid (4), 4'-hydroxy-mycophenolic acid (5) and mycophenolic methyl ester (6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1-3 were elucidated by HRMS, NMR, and Mosher's method. Among them, compounds 1 and 2 were the first examples of mycophenolic acid analogs with a double bond at C-3'/C-4' position. The cytotoxicity of 1-6 was evaluated against the HCT-116, BEL-7402, MGC-803, SH-SY5Y, HO-8910 and HL-60 cell lines, and compounds 4 and 6 showed potent cytotoxicity with IC
