Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp.
10.1016/S1875-5364(20)60026-7
- Author:
Kun-Ya WANG
1
,
2
;
Ping-Lin LI
1
,
2
;
Jing-Fan SUN
1
,
2
;
Nicole J DE VOOGD
3
;
Xu-Li TANG
4
;
Guo-Qiang LI
1
,
5
Author Information
1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2. Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China.
3. National Museum of Natural History, PO Box 9517, 2300 RA Leiden, the Netherlands.
4. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China. Electronic address: tangxuli@ouc.edu.cn.
5. Laboratory of Marine Drugs and Biological Products, National Laboratory of Marine Science and Technology, Qingdao 266235, China. Electronic address: liguoqiang@ouc.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cytotoxic activity;
Plakortis sp.;
Polyhydroxylated steroids
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(11):844-849
- CountryChina
- Language:English
-
Abstract:
Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol (5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
