New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla.
10.1016/S1875-5364(20)60025-5
- Author:
Fei YE
1
,
2
;
Zi-Hui CHEN
1
,
2
;
Yu-Cheng GU
3
;
Yue-Wei GUO
1
,
4
,
5
;
Xu-Wen LI
1
,
4
,
6
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2. University of Chinese Academy of Sciences, Beijing 100049, China.
3. Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom.
4. Open Studio for Druggability Research of Marine Natural Products, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
5. University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: ywguo@simm.ac.cn.
6. University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: xwli@simm.ac.cn.
- Publication Type:Journal Article
- Keywords:
Diterpenes;
Lobane;
Sinularia polydactyla;
Soft coral
- From:
Chinese Journal of Natural Medicines (English Ed.)
2020;18(11):839-843
- CountryChina
- Language:English
-
Abstract:
Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene (1), 8,10,13(15)Z,16E-lobatetraene (2) and 19-hydroxy-lobatetraene (3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien (4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene (5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.
