Hypolipidemic and anti-atherosclerogenic effects of aqueous extract of Ipomoea batatas leaves in diet-induced hypercholesterolemic rats.
10.1016/j.joim.2021.02.002
- Author:
Fidele NTCHAPDA
1
;
Fernand C TCHATCHOUANG
2
;
David MIAFFO
3
;
Barthelemy MAIDADI
2
;
Lorella VECCHIO
4
;
Rodrigue E TALLA
2
;
Christian BONABE
2
;
Paul F SEKE ETET
5
,
6
;
Theophile DIMO
7
Author Information
1. Department of Biological Sciences, University of Ngaoundere, Ngaoundere, Adamawa Region, Cameroon. Electronic address: fiderol@yahoo.com.
2. Department of Biological Sciences, University of Ngaoundere, Ngaoundere, Adamawa Region, Cameroon.
3. Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, Extreme North Region, Cameroon.
4. Center for Sustainable Health and Development, Garoua, North Region, Cameroon.
5. Center for Sustainable Health and Development, Garoua, North Region, Cameroon
6. Department of Physiological Sciences and Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Ngaoundere, Garoua, North Region, Cameroon.
7. Department of Animal Biology and Physiology, University of Yaoundé 1, Yaoundé, Centre Region, Cameroon.
- Publication Type:Journal Article
- Keywords:
Atherosclerotic plaques;
High-density lipoprotein cholesterol;
Hypercholesterolemic rat;
Ipomoea batatas;
Low-density lipoprotein cholesterol;
Very low-density lipoprotein cholesterol
- From:
Journal of Integrative Medicine
2021;19(3):243-250
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Ipomoea batatas (L.) Lam. is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions. We assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of I. batatas leaves in a rat model of diet-induced hypercholesterolemia.
METHODS:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterol-enriched (1%) standard diet for four weeks. Then, rats were treated once daily (per os) with I. batatas extract at doses of 400, 500 and 600 mg/kg or with atorvastatin (2 mg/kg), for four weeks. Following treatment, animals were observed for another four weeks and then sacrificed. Aortas were excised and processed for histopathological studies, and blood glucose level and lipid profile were measured.
RESULTS:Hypercholesterolemic animals experienced a 21.5% faster increase in body weight, significant increases in blood glucose and blood lipids (148.94% triglycerides, 196.97% high-density lipoprotein cholesterol, 773.04% low-density lipoprotein cholesterol, 148.93% very low-density lipoprotein cholesterol and 210.42% total cholesterol), and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard diet. Treatment of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic values.
CONCLUSION:Our findings suggest that I. batatas leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine.
