Effects of moxibustion on Treg cells in sarcoma microenvironment.
10.1016/j.joim.2021.02.001
- Author:
Li-Jun LI
1
;
Yu-Chong SHI
2
;
Min-Xiang LUO
1
;
Chang-Lin ZHAO
3
Author Information
1. Department of Acupuncture, Guangdong Clifford Hospital, Guangzhou 511495, Guangdong Province, China.
2. School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
3. Health Science College, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China. Electronic address: Zhaochanglin120@163.com.
- Publication Type:Journal Article
- Keywords:
Moxibustion;
Sarcoma;
Treg cells;
Tumor microenvironment
- From:
Journal of Integrative Medicine
2021;19(3):251-257
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the therapeutic effect of moxibustion on sarcomas from mesenchymal tissues, which have a low response rate to chemotherapy and radiotherapy.
METHODS:S180 sarcoma cell line was inoculated in C57BL/6 mice to form transplanted tumor. Moxibustion therapy was directly applied at the transplanted tumor sites, at a distance of 3.0 cm, 10 min per session, till skin temperature reached 45 °C, once a day, for 14 consecutive days of intervention. After the mice were killed, serum was collected and used to detect concentrations of interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1), IL-4 and interferon-γ (IFN-γ) by Luminex liquid suspension chip. The numbers of Treg
RESULTS:Weight of S180 transplanted tumor in the control group was (2.03 ± 0.54) g, and that in the moxibustion group was (1.27 ± 0.29) g, which was statistically different (P = 0.023). The mean value of Foxp3
CONCLUSION:Moxibustion may have therapeutic effects on sarcomas by reducing the number of Treg cells in the blood and controlling the infiltration of Treg cells in the TME.
