Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice.
10.1016/j.joim.2020.08.002
- Author:
Olarewaju M OLUBA
1
;
Oghenerobor B AKPOR
2
;
Feyikemi D ADEBIYI
3
;
Sunday J JOSIAH
4
;
Olayinka O ALABI
5
;
Ayoola O SHOYOMBO
5
;
Augustine O OLUSOLA
6
Author Information
1. Department of Biochemistry, Food Safety & Toxicology Research Unit, College of Pure & Applied Sciences, Landmark University, Omu-Aran, Kwara State 251101, Nigeria. Electronic address: oluba.olarewaju@lmu.edu.ng.
2. Department of Microbiology, College of Pure & Applied Sciences, Landmark University, Omu-Aran, Kwara State 251101, Nigeria.
3. Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State 233121, Nigeria.
4. Department of Medical Biochemistry, College of Basic Medical Sciences, Igbinedion University, Okada, Edo State 302110, Nigeria.
5. Department of Animal Science, College of Agricultural Sciences, Landmark University, Omu-Aran, Kwara State 251101, Nigeria.
6. Department of Biochemistry, Adekunle Ajasin University, Akungba Akoko, Ondo State 342111, Nigeria.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory agents;
Antioxidants;
Ganoderma;
Malaria;
Oxidative stress;
Terpenes
- From:
Journal of Integrative Medicine
2020;18(6):522-529
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To understand the protective effects of Ganoderma terpenoid extract (GTE) against Plasmodium berghei-malarial infection in mice, the present study was carried out to evaluate the effects of GTE in combination with chloroquine disulphate (CQ) on erythrocyte-selected inflammatory markers and antioxidant defense status in P. berghei-infected mice.
METHODS:P. berghei-infected mice were divided into six groups: infected control (IC) group, administered 1 mL Tween 20; GTE
RESULTS:Infected mice treated with a combination of GTE and CQ (GT
CONCLUSION:Data generated in this study showed that GTE enhanced the anti-plasmodial action of CQ in mice through its anti-inflammatory and antioxidant activities.
