Metabolism and immunity in breast cancer.
10.1007/s11684-020-0793-6
- Author:
Deyu ZHANG
1
;
Xiaojie XU
2
;
Qinong YE
3
Author Information
1. Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, 100850, China.
2. Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, 100850, China. miraclexxj@126.com.
3. Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, 100850, China. yeqn66@yahoo.com.
- Publication Type:Review
- Keywords:
breast cancer;
cancer stem cells;
immunity;
metabolism
- MeSH:
Breast Neoplasms;
Cell Proliferation;
Cell Transformation, Neoplastic;
Energy Metabolism;
Female;
Humans;
Lipid Metabolism;
Signal Transduction
- From:
Frontiers of Medicine
2021;15(2):178-207
- CountryChina
- Language:English
-
Abstract:
Breast cancer is one of the most common malignancies that seriously threaten women's health. In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasion represent the two main fascinating characteristics of cancer and facilitate cancer cell proliferation. Breast cancer cells generate energy through increased glucose metabolism. Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generation. Amino acids act as basic protein units and metabolic regulators in supporting cell growth. For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancer cells to evade the host's immune system. For the past few years, the complex mechanisms of metabolic reprogramming and immune evasion are deeply investigated, and the genes involved in these processes are used as clinical therapeutic targets for breast cancer. Here, we review the recent findings related to abnormal metabolism and immune characteristics, regulatory mechanisms, their links, and relevant therapeutic strategies.
