Different sites of extranodal involvement may affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma after chimeric antigen receptor T cell therapy.
10.1007/s11684-020-0751-3
- Author:
Lili ZHOU
1
;
Ping LI
1
;
Shiguang YE
1
;
Xiaochen TANG
1
;
Junbang WANG
1
;
Jie LIU
2
;
Aibin LIANG
3
Author Information
1. Department of Hematology, Tongji Hospital of Tongji University, Shanghai, 200065, China.
2. Department of Hematology, Tongji Hospital of Tongji University, Shanghai, 200065, China. liujie3131@hotmail.com.
3. Department of Hematology, Tongji Hospital of Tongji University, Shanghai, 200065, China. lab7182@tongji.edu.cn.
- Publication Type:Journal Article
- Keywords:
anti-CD19 chimeric antigen receptor T cell;
bone marrow;
relapsed or refractory non-Hodgkin lymphoma;
soft tissue
- MeSH:
Cell- and Tissue-Based Therapy;
Humans;
Immunotherapy, Adoptive;
Lymphoma, Non-Hodgkin/therapy*;
Receptors, Antigen, T-Cell;
Receptors, Chimeric Antigen
- From:
Frontiers of Medicine
2020;14(6):786-791
- CountryChina
- Language:English
-
Abstract:
Factors associated with complete and durable remissions after anti-CD19 chimeric antigen receptor T (CAR-T) cell immunotherapy for relapsed or refractory non-Hodgkin lymphoma (r/r NHL) have not been well characterized. In this study, we found that the different sites of extranodal involvement may affect response, overall survival (OS), and progression-free survival (PFS) in patients with r/r NHL treated with anti-CD19 CAR-T cells. In a cohort of 32 treated patients, 12 (37.5%) and 8 (25%) patients exhibited soft tissue lymphoma and bone marrow (BM) infiltrations, respectively, and 13 (41%) patients exhibited infiltration at other sites. The factors that may affect prognosis were identified through multivariable analysis. As an independent risk factor, soft tissue infiltration was the only factor significantly correlated with adverse prognosis (P < 0.05), whereas other factors did not reach statistical significance. Furthermore, the site of extranodal tumor infiltration significantly and negatively affected OS and PFS in patients with r/r NHL treated with anti-CD19 CAR-T cell therapy. PFS and OS in patients with BM involvement were not significantly different from those of patients with lymph node involvement alone. Thus, anti-CD19 CAR-T cell therapy may improve the prognosis of patients with BM infiltration.
