Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial infarction.
10.1007/s11684-020-0749-x
- Author:
Hui WANG
1
;
Yang ZHANG
1
;
Zhujun SHEN
1
;
Ligang FANG
1
;
Zhenyu LIU
2
;
Shuyang ZHANG
3
Author Information
1. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
2. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. pumch_lzy@163.com.
3. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. shuyangzhang103@nrdrs.org.
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
fasting glucose;
heart failure;
myocardial infarction;
percutaneous coronary intervention
- MeSH:
Aged;
Fasting;
Female;
Glucose;
Heart Failure;
Humans;
Male;
Middle Aged;
Percutaneous Coronary Intervention;
Prognosis;
Retrospective Studies;
Risk Factors;
ST Elevation Myocardial Infarction/surgery*
- From:
Frontiers of Medicine
2021;15(1):70-78
- CountryChina
- Language:English
-
Abstract:
Recent studies have shown that acute blood glucose elevation in patients with ST-segment elevation myocardial infarction (STEMI) suggests a poor prognosis. To investigate the effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular systolic dysfunction (LVSD) in non-diabetic patients undergoing primary percutaneous coronary intervention (PCI) for acute STEMI, we retrospectively recruited consecutive non-diabetic patients who underwent primary PCI for STEMI in our hospital from February 2003 to March 2015. The patients were divided into two groups according to the FBG level. A total of 623 patients were recruited with an age of 61.3 ± 12.9 years, of whom 514 (82.5%) were male. The HF risk (odds ratio 3.401, 95% confidence interval (CI) 2.144-5.395, P < 0.001) was significantly increased in patients with elevated FBG than those with normal FBG. Elevated FBG was also independently related to LVSD (β 1.513, 95%CI 1.282-1.785, P < 0.001) in a multiple logistics regression analysis. In conclusion, elevated FBG was independently associated with 30-day HF and LVSD risk in non-diabetic patients undergoing primary PCI for STEMI.
