Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study.
10.1007/s11684-019-0723-7
- Author:
Di CHENG
1
;
Chunyan HU
1
;
Rui DU
1
;
Hongyan QI
1
;
Lin LIN
1
;
Xueyan WU
1
;
Lina MA
1
;
Kui PENG
1
;
Mian LI
1
;
Min XU
1
;
Yu XU
1
;
Yufang BI
1
;
Weiqing WANG
1
;
Yuhong CHEN
2
;
Jieli LU
3
Author Information
1. Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
2. Department of Endocrine and Metabolic Diseases, Ruijin Hospital North, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201821, China. chenyh70@126.com.
3. Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. jielilu@hotmail.com.
- Publication Type:Journal Article
- Keywords:
incident diabetes;
prospective study;
uric acid
- MeSH:
Adult;
Aged;
China/epidemiology*;
Diabetes Mellitus/epidemiology*;
Female;
Humans;
Incidence;
Male;
Middle Aged;
Prospective Studies;
Risk Factors;
Uric Acid
- From:
Frontiers of Medicine
2020;14(6):802-810
- CountryChina
- Language:English
-
Abstract:
The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown. This study aimed to investigate this association in a community-dwelling population aged ≥ 40 years in Shanghai, China. Oral glucose tole3rance test was conducted during baseline and follow-up visits. Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk. A total of 613 (10.3%) incident diabetes cases were identified during the follow-up visit after 4.5 years. Fasting plasma glucose, postload glucose, and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid (all Ps < 0.05). The incidence rate of diabetes increased across the quartiles of serum uric acid (7.43%, 8.77%, 11.47%, and 13.43%). Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid (odds ratio (95% confidence interval) = 1.36 (1.06-1.73)). Stratified analysis indicated that the association was only observed in women. Accordingly, serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.
