Potentiating CD8

Juanjuan Yuan; Ting Cai; Xiaojun Zheng; Yangzi Ren; Jingwen QI; Xiaofei LU; Huihui Chen; Huizhen Lin; Zijie Chen; Mengnan Liu; Shangwen HE; Qijun Chen; Siyang Feng; Yingjun WU; Zhenhai Zhang; Yanqing Ding; Wei Yang

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Potentiating CD8

Author: Juanjuan YUAN ¹ ; Ting CAI ¹ ; Xiaojun ZHENG ² ; Yangzi REN ² ; Jingwen QI ² ; Xiaofei LU ² ; Huihui CHEN ² ; Huizhen LIN ² ; Zijie CHEN ² ; Mengnan LIU ² ; Shangwen HE ² ; Qijun CHEN ² ; Siyang FENG ² ; Yingjun WU ² ; Zhenhai ZHANG ³ ; Yanqing DING ⁴ ; Wei YANG ⁵
Author Information

1. Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, 528308, China.
2. Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
3. Center for Precision Medicine, Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510030, China. zhenhaismu@163.com.
4. Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. dyqgz@126.com.
5. Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. yanglab@smu.edu.cn.
Publication Type:Journal Article
Keywords: CD8+ T cells; LDLR; PCSK9; TCR; cancer immunotherapy; tumor microenvironment
From: Protein & Cell 2021;12(4):240-260
CountryChina
Language:English
Abstract: Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as a key component of this regulation remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which has been previously identified as a transporter for cholesterol, plays a pivotal role in regulating CD8