Role of gut microbiota in identification of novel TCM-derived active metabolites.
10.1007/s13238-020-00784-w
- Author:
Tzu-Lung LIN
1
;
Chia-Chen LU
2
;
Wei-Fan LAI
3
;
Ting-Shu WU
3
;
Jang-Jih LU
4
;
Young-Mao CHEN
5
;
Chi-Meng TZENG
6
;
Hong-Tao LIU
7
;
Hong WEI
8
;
Hsin-Chih LAI
9
Author Information
1. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan, 33302, Taiwan, China.
2. Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, 24205, Taiwan, China.
3. Department of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan, China.
4. Department of Laboratory Medicine and Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, 33305, Taiwan, China.
5. Bachelor Degree Program in Marine Biotechnology, College of Life Sciences, National Taiwan Ocean University, Keelung, 20224, Taiwan, China.
6. School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361005, China.
7. College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
8. Central Laboratory, Clinical Medicine Scientific and Technical Innovation Park, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200435, China.
9. Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Gueishan, Taoyuan, 33302, Taiwan, China. hclai@mail.cgu.edu.tw.
- Publication Type:Review
- Keywords:
Traditional Chinese Medicine;
herbs;
microbiota;
multiomics;
transformation
- From:
Protein & Cell
2021;12(5):394-410
- CountryChina
- Language:English
-
Abstract:
Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
