Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.

Lin Zhao; Songguo Xue; Zhongyuan Yao; Juanzi Shi; Biaobang Chen; Ling WU; Lihua Sun; Yao XU; Zheng Yan; Bin LI; Xiaoyan Mao; Jing FU; Zhihua Zhang; Jian MU; Wenjing Wang; Jing DU; Shuai Liu; Jie Dong; Weijie Wang; Qiaoli LI; Lin HE; Li Jin; Xiaozhen Liang; Yanping Kuang; Xiaoxi Sun; Lei Wang; Qing Sang

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Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development.

Author: Lin ZHAO ¹ ; Songguo XUE ² ; Zhongyuan YAO ³ ; Juanzi SHI ⁴ ; Biaobang CHEN ⁵ ; Ling WU ⁶ ; Lihua SUN ² ; Yao XU ² ; Zheng YAN ⁶ ; Bin LI ⁶ ; Xiaoyan MAO ⁶ ; Jing FU ⁷ ; Zhihua ZHANG ¹ ; Jian MU ¹ ; Wenjing WANG ¹ ; Jing DU ⁵ ; Shuai LIU ⁸ ; Jie DONG ¹ ; Weijie WANG ¹ ; Qiaoli LI ¹ ; Lin HE ⁹ ; Li JIN ¹⁰ ; Xiaozhen LIANG ⁸ ; Yanping KUANG ⁶ ; Xiaoxi SUN ⁷ ; Lei WANG ¹¹ ; Qing SANG ¹²
Author Information

1. Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China.
2. Center of Assisted Reproduction, Shanghai East hospital, Tongji University, Shanghai, 200120, China.
3. The Reproductive Medical Center of Xiangya Hospital, Central South University, Changsha, 41008, China.
4. Reproductive Medicine Center, Shaanxi Maternal and Child Care Service Center, Xi'an, 710069, China.
5. NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, 200032, China.
6. Reproductive Medicine Center, Shanghai Ninth Hospital, Shanghai Jiao Tong University, Shanghai, 200011, China.
7. Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.
8. Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
9. Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China.
10. State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200438, China.
11. Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China. wangleiwanglei@fudan.edu.cn.
12. Institute of Pediatrics, Children's Hospital of Fudan University and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and metabolism, Ministry of Science and technology and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, 200032, China. sangqing@fudan.edu.cn.
Publication Type:Letter
MeSH: Animals; Cdc20 Proteins/metabolism*; Cell Line; Embryo, Mammalian/embryology*; Embryonic Development; Female; Infertility, Female/metabolism*; Mice; Mutation; Oocytes/metabolism*
From: Protein & Cell 2020;11(12):921-927
CountryChina
Language:English