Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.
- Author:
Weiwei JIANG
1
;
Fangfang CAI
1
;
Huangru XU
1
;
Yanyan LU
1
;
Jia CHEN
1
;
Jia LIU
1
;
Nini CAO
1
;
Xiangyu ZHANG
1
;
Xiao CHEN
1
;
Qilai HUANG
1
;
Hongqin ZHUANG
2
;
Zi-Chun HUA
3
Author Information
- Publication Type:Research Support, Non-U.S. Gov't
- Keywords: EMT; ERK5; FAK; USF1; lung cancer; melanoma; metastasis
- MeSH: A549 Cells; Animals; Cell Movement; Epithelial-Mesenchymal Transition/genetics*; Focal Adhesion Kinase 1/metabolism*; Humans; Lung Neoplasms/pathology*; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 7/metabolism*; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins/metabolism*
- From: Protein & Cell 2020;11(11):825-845
- CountryChina
- Language:English
- Abstract: This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser
