Individualized plasticity autograft mimic with efficient bioactivity inducing osteogenesis.
10.1038/s41368-021-00120-w
- Author:
Yan WEI
1
;
Guixin ZHU
1
;
Zifan ZHAO
1
;
Chengcheng YIN
1
;
Qin ZHAO
1
;
Hudi XU
2
;
Jinyang WANG
1
;
Jinglun ZHANG
1
;
Xiaoxin ZHANG
2
;
Yufeng ZHANG
1
;
Haibin XIA
3
Author Information
1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
2. Department of Oral Implantology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
3. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China. xhaibin@whu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Autografts;
Bone Regeneration;
Cell Differentiation;
Humans;
Mesenchymal Stem Cells;
Osteogenesis;
Tissue Engineering;
Tissue Scaffolds
- From:
International Journal of Oral Science
2021;13(1):14-14
- CountryChina
- Language:English
-
Abstract:
Mineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration. At present, autograft harvest procedures may cause secondary trauma to patients, while bone scaffold materials lack osteogenic activity, resulting in a limited application. Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft, but the explosive release of growth factor may also cause side effects. In this study, we innovatively used platelet-rich fibrin (PRF)-modified bone scaffolds (Bio-Oss
