FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma.
10.1038/s41368-021-00111-x
- Author:
Yilong HAO
1
;
Yanxuan XIAO
2
;
Xiaoyu LIAO
2
;
Shuya TANG
2
;
Xiaoyan XIE
3
;
Rui LIU
4
;
Qianming CHEN
5
Author Information
1. The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu, China.
3. Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, China.
4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu, China. liurui_scu@hotmail.com.
5. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management & West China Hospital of Stomatology, Sichuan University, Chengdu, China. qmchen@zju.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Animals;
Carcinoma, Squamous Cell;
Cell Line, Tumor;
Cell Movement;
Epithelial-Mesenchymal Transition;
Fibroblast Growth Factor 8;
Head and Neck Neoplasms;
Humans;
Mice;
Mouth Neoplasms;
Neoplasm Recurrence, Local;
Squamous Cell Carcinoma of Head and Neck
- From:
International Journal of Oral Science
2021;13(1):6-6
- CountryChina
- Language:English
-
Abstract:
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent growth factors, fibroblast growth factors (FGFs) are frequently susceptible to being hijacked by cancer cells. In this study, we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters, including age, drinking, and survival time. FGF8 treatment enhances the invasive capability of OSCC cells. Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model. Further, mechanistic study demonstrates that FGF8 induces epithelial-mesenchymal transition (EMT) in OSCC cells. These results highlight a pro-metastatic function of FGF8, and underscore the role of FGF8 in OSCC development.
