Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration.
10.1038/s41368-020-00100-6
- Author:
Anqi LIU
1
;
Shanshan JIN
2
;
Cuicui FU
3
;
Shengji CUI
2
;
Ting ZHANG
2
;
Lisha ZHU
2
;
Yu WANG
2
;
Steve G F SHEN
4
;
Nan JIANG
5
;
Yan LIU
6
Author Information
1. Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
2. Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
3. Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Gustav Mahlerlaan 3004, Amsterdam, The Netherlands.
4. Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China. shengf@sumhs.edu.cn.
5. Central Laboratory, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China. nanjiang@bjmu.edu.cn.
6. Laboratory of Biomimetic Nanomaterials, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China. orthoyan@bjmu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Biomimetics;
Bone Regeneration;
Cell Differentiation;
Collagen;
Extracellular Vesicles;
Macrophages;
Osteogenesis
- From:
International Journal of Oral Science
2020;12(1):33-33
- CountryChina
- Language:English
-
Abstract:
Macrophages play an important role in material-related immune responses and bone formation, but the functionality of macrophage-derived extracellular vesicles (EVs) in material-mediated bone regeneration is still unclear. Here, we evaluated intracellular communication through small extracellular vesicles (sEVs) and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen (IMC). After implantation in the bone defect area, IMC generated more neobone and recruited more mesenchymal stem cells (MSCs) than did extrafibrillarly mineralized collagen (EMC). More CD63
