Overexpression of lncRNA MEG3 inhibits proliferation and invasion of glioblastoma U251 cells
10.12122/j.issn.1673-4254.2021.01.21
- Author:
Qizhi LUO
1
;
Fan ZHANG
2
;
Wei LI
2
;
Fang WANG
2
;
Lixiang WU
2
;
Baisheng HUANG
2
Author Information
1. Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha 410008, China.
2. Department of Physiology, School of Basic Medical Sciences, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- Keywords:
glioblastoma;
hypoxia inducible factor 1 alpha;
invasion;
long noncoding RNA MEG3;
proliferation
- MeSH:
Apoptosis;
Cell Line, Tumor;
Cell Movement/genetics*;
Cell Proliferation/genetics*;
Gene Expression Regulation, Neoplastic;
Glioblastoma/genetics*;
Humans;
MicroRNAs;
RNA, Long Noncoding/genetics*
- From:
Journal of Southern Medical University
2021;41(1):141-145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of overexpression of long noncoding RNA (lncRNA) MEG3 on the proliferation and invasion of glioblastoma U251 cells by suppressing the expression of hypoxia inducible factor 1
METHODS:The expression of lncRNA MEG3 and HIF1
RESULTS:The expression of MEG3 was significantly lower and HIF1
CONCLUSIONS:MEG3 overexpression inhibits the proliferation and invasion of U251 cells through suppressing the expression of HIF1
