Effect of general anesthesia on postoperative melatonin secretion in 4-to 6-year-old children with snoring.
10.12122/j.issn.1673-4254.2021.01.19
- Author:
Qianqi QIU
1
;
Xingrong SONG
1
;
Changzhi SUN
2
;
Yonghong TAN
1
;
Yingyi XU
1
;
Guiliang HUANG
2
;
Na ZHANG
1
;
Zhengke LI
2
;
Wei WEI
1
Author Information
1. Department of Anesthesiology, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou 510623, China.
2. Department of Otolaryngology, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou 510623, China.
- Publication Type:Journal Article
- Keywords:
children;
circadian rhythm;
general anesthesia;
melatonin;
sleep;
snoring
- MeSH:
Anesthesia, General/adverse effects*;
Bodily Secretions;
Child;
Child, Preschool;
Circadian Rhythm;
Humans;
Melatonin;
Snoring
- From:
Journal of Southern Medical University
2021;41(1):128-134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effect of general anesthesia on postoperative melatonin secretion in 4-to 6-year-old children with snoring.
METHODS:Twenty children with snoring aged 4-6 years of either gender (ASA grade Ⅰ and Ⅱ) were selected for adenoidectomy.Before, during and 3 days after the operation, salivary melatonin levels of the children were measured at 11 selected time points (T1-T11).The illumination intensity and body temperature of the children were recorded at each time point of measurement.The sleep time of the children in 3 days after the operation was recorded, and postoperative pain scores (FLACC) and Riker and Rehabilitation Quality Rating Scale-15(QoR-15) scores were assessed.Sleep Apnea Life Quality Evaluation Questionnaire (OSA-18) was used to evaluate postoperative recovery of the children at 28 days after the operation.The incidence of major adverse events of the children during hospitalization was recorded.
RESULTS:No significant difference was found in baseline salivary melatonin level among the 20 children before the operation.Salivary melatonin level at 7 am after the operation (T8) was significantly lowered as compared with that before the surgery (T4)(
CONCLUSIONS:In preschool children with snoring, general anesthesia affects but does not inhibit melatonin secretion on the first night after surgery, and minor surgeries under general anesthesia in the morning do not cause significant changes in melatonin secretion to cause disturbance of the circadian rhythm in these children.
