Effects of bisphenol A on apoptosis of ovarian preantral follicular granulosa cells and ovarian development in mice.
10.12122/j.issn.1673-4254.2021.01.13
- Author:
Meng LIANG
1
;
Jinzhao ZHOU
1
;
Xunying SUN
1
;
Chaofan HE
1
;
Kejia ZHANG
1
;
Ke HU
1
Author Information
1. School of Life Science, Bengbu Medical College, Bengbu 233030, China.
- Publication Type:Journal Article
- Keywords:
bisphenol A;
mitochondrial membrane potential;
ovary;
preantral follicular granulosa cells
- MeSH:
Animals;
Apoptosis;
Benzhydryl Compounds;
Female;
Granulosa Cells;
Mice;
Mice, Inbred ICR;
Ovarian Follicle;
Phenols;
Pregnancy
- From:
Journal of Southern Medical University
2021;41(1):93-99
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of environmental estrogen bisphenol A (BPA) exposure on apoptosis of mouse ovarian preantral follicular granulosa cells and ovarian development and explore the underlying mechanism.
METHODS:Mouse ovarian preantral follicular granulosa cells were isolated from female ICR mice at postnatal day (PND) 10 and cultured
RESULTS:Compared with the control cells group, the isolated cells exposed to a low concentration of BPA (50 μmol/L) showed a significantly lowered apoptosis rate, increased mitochondrial membrane potential, and enhanced cellular proliferation (
CONCLUSIONS:BPA can concentration-dependently regulate the function of ovarian preantral follicular granulosa cells in mice and potentially affects both the pregnant mice and the offspring female mice in light of early ovarian development.
