Establishment of a mouse model bearing orthotopic temozolomide-resistant glioma.

Author: Linyong SHI ¹ ; Hong LI ¹ ; Junwei GU ¹ ; Chong SONG ¹ ; Junjie LI ¹ ; Lei CHEN ¹ ; Qiang ZHOU ¹ ; Songtao QI ¹ ; Yuntao LU ¹
Author Information

1. Department of Neurosurgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China.
Publication Type:Journal Article
Keywords: animal model; glioma; temozolomide resistance
MeSH: Animals; Antineoplastic Agents, Alkylating/pharmacology*; Brain Neoplasms/drug therapy*; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma/drug therapy*; Mice; Mice, Inbred C57BL; Temozolomide/therapeutic use*
From: Journal of Southern Medical University 2021;41(1):69-74
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To establish a mouse model bearing orthotopic temozolomide (TMZ)-resistant glioma that mimics the development of drug resistance in gliomas
METHODS:Seventy-eight adult C57BL/6 mice were randomly divided into 6 groups (
RESULTS:The mouse models bearing TMZresistant glioma was successfully established. The cells from the high-dose induced group showed a significantly higher colony-forming rate than those from the high-dose control group (
CONCLUSIONS:Progressive increase of TMZ doses in mice bearing orthotopic gliomas can effectively induce TMZ resistance of the gliomas.