Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation.
10.12122/j.issn.1673-4254.2021.01.04
- Author:
Kun ZHANG
1
;
Zhemin SHI
1
;
Yi REN
1
;
Xiaohui HAN
1
;
Jingzhao WANG
1
;
Wei HONG
1
Author Information
1. Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
- Publication Type:Journal Article
- Keywords:
Kcnq1ot1;
osteoclastogenesis;
osteogenesis;
osteoporosis
- MeSH:
Animals;
Cell Differentiation;
Cells, Cultured;
Mice;
Osteoblasts;
Osteoclasts;
Osteogenesis
- From:
Journal of Southern Medical University
2021;41(1):31-38
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the regulatory role of long non-coding RNA Kcnq1ot1 in osteoclast differentiation, osteogenic differentiation and osteoporosis.
METHODS:The expression of lnc-Kcnq1ot1, Bglap, Runx2, Alp, Bsp, Nfatc1, Mmp9, Ctsk and Oscar were detected by real-time quantitative PCR (qRT-PCR) in the femoral bones from mouse models of postmenopausal osteoporosis (ovariectomized mice,
RESULTS:The expression of lnc-Kcnq1ot1 was significantly upregulated during osteoblast differentiation but downregulated in the bone tissues of osteoporotic mice and during osteoclast differentiation (
CONCLUSIONS:Our data demonstrate that lnc-Kcnq1ot1 promotes osteogenic differentiation and alleviates osteoclast differentiation, suggesting the potential of lnc-Kcnq1ot1 as a therapeutic target against osteoporosis.
