SBi4211 alleviates gp120-induced central nervous system injury

Shaojie Yang; Xiaoyan Deng; Tiesong Zhang; Yi Xiao; Liang Peng; Li LI; Xiaolong HE; Yi Wei; Liqun Liu; Hong Cao; Beiguo Long; Shenghe Huang

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SBi4211 alleviates gp120-induced central nervous system injury

Author: Shaojie YANG ¹ ; Xiaoyan DENG ² ; Tiesong ZHANG ³ ; Yi XIAO ⁴ ; Liang PENG ⁴ ; Li LI ³ ; Xiaolong HE ¹ ; Yi WEI ¹ ; Liqun LIU ⁵ ; Hong CAO ¹ ; Beiguo LONG ¹ ; Shenghe HUANG ¹
Author Information

1. Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
2. KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 511436, China.
3. Kunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming 650228, China.
4. Department of Clinical Laboratory, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China.
5. Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Publication Type:Journal Article
Keywords: HIV-associated neurocognitive disorder; S100B/RAGE; SBi4211; gp120
MeSH: Animals; Astrocytes; Blotting, Western; Central Nervous System; HIV Envelope Protein gp120; Mice; Neurons; S100 Calcium Binding Protein beta Subunit; Signal Transduction
From: Journal of Southern Medical University 2020;40(12):1693-1702
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To explore the protective effect of SBi4211 (heptamidine), an inhibitor of S100B, against central nervous system injury induced by HIV-1 envelope protein gp120.
METHODS:In an
RESULTS:In the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (
CONCLUSIONS:SBi4211 can protect neurons from gp120-induced neurotoxicity possibly by inhibiting the S100B/ RAGE-mediated signaling pathway.