Mitochondrial G12630A variation is associated with statin-induced myalgia in Chinese patients with coronary artery disease.
10.12122/j.issn.1673-4254.2020.12.08
- Author:
Xiaohong ZHOU
1
;
Zixian WANG
2
;
Min QIN
2
;
Shilong ZHONG
1
Author Information
1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
2. Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
- Publication Type:Journal Article
- Keywords:
mitochondrial DNA;
myalgia;
single nucleotide polymorphism;
statin
- MeSH:
China;
Coronary Artery Disease/genetics*;
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects*;
Mitochondria;
Myalgia;
Polymorphism, Single Nucleotide
- From:
Journal of Southern Medical University
2020;40(12):1747-1752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To identify mitochondrial gene variants associated with statin-induced myalgia in Chinese patients with coronary artery disease (CHD).
METHODS:This study was conducted in a cohort of 403 patients with CHD receiving rosuvastatin therapy, among whom 341 patients had complete follow-up data concerning myalgia and 389 patients had documented measurements of plasma creatine kinase (CK) level. All these patients underwent genetic analysis using GSA chip for detecting mitochondria gene variants associated with myalgia. A logistic regression model was used to assess the association between 69 mitochondrial single-nucleotide polymorphisms (SNPs) and myopathy in 341 patients. The impact of these mutation sites on CK levels in 389 patients was evaluated by linear regression analysis.
RESULTS:G12630A variant was identified to correlate with an increased risk of myalgia in CHD patients (OR: 8.689, 95%
CONCLUSIONS:Mitochondrial G12630A variation is associated with statin-induced myalgia in patients with CHD, indicating the necessity of different treatment strategies for patients who carry this risk allele.
